MSH2

MSH2

278.001,300.00

MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown Anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic tissues, and for identifying a loss of MSH2 in tumors that are microsatellite-unstable.

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Image Variation SKU Price Quantity Add To Cart
MSH2-IHC410-Esophagus 0.1ml - IHC410-100 278.00
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MSH2-IHC410-Esophagus 1ml; - IHC410-1 1,300.00
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MSH2-IHC410-Esophagus Positive Control - IHC410-PC 770.00
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Description

CE-IVD registered and supplied as a concentrate.

Specifications

Clone IHC410
Source Mouse Monoclonal
Positive Control Colon Mucosa, Colon Carcinoma
Dilution Range 1:100 – 1:200

References

  1. Pal T, et al. Cancer. 2008; 113:733-42.
  2. Brueckl WM, et al. Anticancer Res. 2003; 23:1773-8.
  3. Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.
  4. Renkonen E, et al. J Clin Oncol. 2003; 21:3629-37.
  5. Hoedema R, et al. Am Surg. 2003; 69:387-92.
  6. Christensen M, et al. Cancer. 2002; 95:2422-30.
  7. Wahlberg SS, et al. Cancer Res. 2002; 62:3485-92.
  8. Lanza G, et al. Mod Pathol. 2002; 15:741-9.
  9. Thibodeau SN, et al. Cancer Res 1996; 56:4836-40.

Additional information

Unit

0.1ml, 1ml;, Positive Control

Documents

Instructions for Use

Safety Data Sheet

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