p53

p53

231.00936.00

p53, also known as tumor protein 53 or TP53, is a tumor suppressor and transcription factor that functions in a number of anti-cancer activities including DNA repair, cell-cycle arrest, and apoptosis in response to DNA damage or other stressors. Mutations in p53 are linked to a number of malignant tumors, including those of the breast, ovarian, bladder, colon, lung, and melanoma. Anti-p53 staining has been used to detect intratubular germ cell neoplasia, and also to distinguish between uterine serous carcinoma and endometrioid carcinoma.

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Image Variation SKU Price Quantity Add To Cart
p53-IHC053-Colon-Cancer 0.1ml - IHC053-100 231.00
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p53-IHC053-Colon-Cancer 1ml - IHC053-1 936.00
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p53-IHC053-Colon-Cancer Positive Control - IHC053-PC 553.00
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Description

CE-IVD registered and supplied as a concentrate.

Specifications

Clone IHC053
Source Mouse Monoclonal
Positive Control Colon Carcinoma
Dilution Range 1:100 – 1:200

References

  1. Stoehlmacker J, et al. Oncol. 2003; 30:10-16.
  2. Gallo O, et al. Hum Pathol. 2002; 33:708-714.
  3. Sano H, et al. Cancer Res. 1995: 55:3785-9.
  4. Denkert C, et al. Cancer. 2003; 97:2978-87.
  5. Sheehan KM, et al. Hum Pathol. 2003; 34:1242-1246.
  6. Moore BE, et al. Appl Immunohistochem Mol Morphol. 2001; 9:203-6.
  7. Mauri FA, et al. Int J Oncol. 1999; 15:1137-47.
  8. Caffo O, et al. Clin Cancer Res. 1996; 2:1591-9.
  9. Bebenek M, et al. Anticancer Res. 1998; 18:619-23.
  10. Midulla C, et al. Anticancer Res. 1999; 19:4033-7.
  11. Zen ZS, et al. J Clin Oncol. 1994; 12:2043-50.
  12. Quinlan DC, et al. Cancer Res. 1992; 53:4828-31.
  13. Alexiev BA, et al. Gen Diagn Pathol. 1997; 142:271-9.

Additional information

Unit

0.1ml, 1ml, Positive Control

Documents

Instructions for Use

Safety Data Sheet

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