Thymidylate Synthase

Thymidylate Synthase

578.003,224.00

Thymidylate Synthase (TS) is a crucial enzyme responsible for the synthesis of 2′-deoxythymidine-5′-monophosphate (dTMP) a precursor for thymidylate which is necessary for DNA replication and repair from 2′-deoxyuridine-5′-monophosphate (dUMP). In terms of cancer, TS is an important target for cancer treatment as the inhibition of TS and therefore nucleotide synthesis necessary for cell growth has shown to be a vital part for successful treatment against colorectal, pancreatic and breast cancers.

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Image Variation SKU Price Quantity Add To Cart
Thymidylate_Synthase-IHC697-Breast 0.1ml - IHC697-100 578.00
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Thymidylate_Synthase-IHC697-Breast 1ml - IHC697-1 3,224.00
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Thymidylate_Synthase-IHC697-Breast Positive Control - IHC697-PC 962.00
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Description

CE-IVD registered and supplied as a concentrate

Specifications

Clone IHC697
Source Mouse Monoclonal
Positive Control Colon Cancer
Dilution Range 1:100 – 1:200

References

  1. Rose, M. G., Farrell, M. P., & Schmitz, J. C. (2002). Thymidylate synthase: a critical target for cancer chemotherapy. Clinical colorectal cancer, 1(4), 220-229.
  2. Peters, G. J., Backus, H. H. J., Freemantle, S., Van Triest, B., Codacci-Pisanelli, G., Van der Wilt, C. L.& McLeod, H. L. (2002). Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1587(2-3), 194-205..

Additional information

Unit

0.1ml, 1ml, Positive Control

Documents

Instructions for Use

Safety Data Sheet

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